Vascular endothelial growth factor expression up-regulated by endometrial ischemia in secretory phase plays an important role in endometriosis

被引：23
|
作者：
Ren, Qiong-zhen [1 ]
Qian, Zhi-hong [1 ]
Jia, Su-hong [1 ]
Xu, Zhen-zhen [1 ]
机构：
[1] Soochow Univ, Hosp 2, Dept Obstet & Gynecol, Suzhou 215004, Jiangsu, Peoples R China
来源：
FERTILITY AND STERILITY | 2011年 / 95卷 / 08期
关键词：
Ischemic preconditioning; hypoxia; VEGF; endometriosis; CYCLE;
D O I：
10.1016/j.fertnstert.2011.05.001
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Primary human endometrial cells were exposed to hypoxia preconditioning (HPC), HPC-hypoxia, and hypoxia conditions, and then endometrial tissue treated with ischemia preconditioning (IPC) was transplanted onto the chick embryo chorioallantoic membrane to investigate the role of slight ischemia of endometrium in the pathologic process of endometriosis. IPC up-regulated vascular endothelial growth factor expression and decreased apoptosis of endometrial cells, thus facilitating the endometrial fragments' ectopic implantation. (Fertil Steril (R) 2011;95:2687-9. (C) 2011 by American Society for Reproductive Medicine.)
引用
收藏
页码：2687 / 2689
页数：3
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