Pharmacogenomics: an opportunity for personalised psychotropic prescribing in adults with intellectual disabilities

被引：1

作者：

Perera, Bhathika ^{[1
]}

Steward, Charles ^{[2
]}

Courtenay, Ken ^{[1
]}

Andrews, Timothy ^{[3
]}

Shankar, Rohit ^{[4
,5
]}

机构：

[1] Barnet Enfield & Haringey Mental Hlth NHS Trust, London, England

[2] Congen Ltd, Cambridge, England

[3] Oxford Hlth NHS Fdn Trust, Oxford, England

[4] Univ Plymouth, Peninsula Sch Med, Plymouth, Devon, England

[5] Cornwall Partnership NHS Fdn Trust, Truro, England

来源：

BJPSYCH OPEN | 2022年 / 8卷 / 05期

关键词：

Intellectual disabilities; genetics; polypharmacy; psychotropics; discrimination;

D O I：

10.1192/bjo.2022.554

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

There is growing evidence for the use of pharmacogenomics in psychotropic prescribing. People with intellectual disabilities are disproportionately prescribed psychotropics and are at risk of polypharmacy. There is an urgent need for safeguards to prevent psychotropic overprescribing but it is equally crucial that this population is not left behind in such exciting initiatives. Understanding how genetic variations affect medications is a step towards personalised medicine. This may improve personalised prescribing for people with intellectual disabilities, especially given the high rate of psychiatric and behavioural problems in this population. Our editorial explores opportunities and challenges that pharmacogenomics offers for the challenges of polypharmacy and overprescribing of psychotropics in people with intellectual disabilities.

引用

页数：3

共 50 条

[1] International guide to prescribing psychotropic medication for the management of problem behaviours in adults with intellectual disabilities
Deb, Shoumitro
Kwok, Henry
Bertelli, Marco
Salvador-Carulla, Luis
Bradley, Elspeth
Torr, Jennifer
Barnhill, Jarret
[J]. WORLD PSYCHIATRY, 2009, 8 (03) : 181 - 186
[2] Prescribing psychotropic drugs to adults with an intellectual disability
Trollor, Julian N.
Salomon, Carmela
Franklin, Catherine
[J]. AUSTRALIAN PRESCRIBER, 2016, 39 (04) : 126 - 130
[3] ACCURACY OF PSYCHOTROPIC MEDICATION IN ADULTS WITH INTELLECTUAL DISABILITIES
Hove, O.
Biringer, E.
Havik, O. E.
[J]. EUROPEAN PSYCHIATRY, 2010, 25
[4] The Health Improvement Network: Analysis of psychotropic prescribing patterns for adults with intellectual disabilities and challenging behaviour
Hassiotis, A.
[J]. JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2016, 60 (7-8) : 677 - 677
[5] Psychotropic Prescribing for Persons With Intellectual Disabilities and Other Psychiatric Disorders
Edelsohn, Gail A.
Schuster, James M.
Castelnovo, Kim
Terhorst, Lauren
Parthasarathy, Meghna
[J]. PSYCHIATRIC SERVICES, 2014, 65 (02) : 201 - 207
[6] Prescribing psychotropic medication for problem behaviours in adults with intellectual disabilities in a specialist psychiatric unit in Hong Kong
Kwok, Henry
Chui, Eileena
Tang, Alexander
[J]. ADVANCES IN MENTAL HEALTH AND INTELLECTUAL DISABILITIES, 2010, 4 (03) : 27 - 33
[7] Psychotropic prescribing by general practitioners for people with intellectual and developmental disabilities in England
Glover, G.
Williams, R.
Branford, D.
Avery, R.
Chauhan, U.
Hoghton, M.
[J]. JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2016, 60 (7-8) : 672 - 672
[8] QUALITATIVE EXPLORATION OF PSYCHOTROPIC MEDICATION PRESCRIBING FOR ADULTS WITH INTELLECTUAL DISABILITY
Sheehan, R.
Strydom, A.
Hassiotis, A.
Morant, N.
[J]. JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2019, 63 (07) : 678 - 678
[9] A PRESCRIBING TOOL FOR CHALLENGING BEHAVIOR IN ADULTS WITH INTELLECTUAL DISABILITIES
Lonchampt, S.
Gerber, F.
Aubry, J. -M.
Desmeules, J.
Besson, M.
Kosel, M.
[J]. JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2019, 63 (07) : 688 - 688
[10] Determinants of psychotropic medication in adults with mild or moderate intellectual disabilities
Schuetzwohl, M.
Voss, E.
Stiawa, M.
Salize, H. -J.
Puschner, B.
Koch, A.
[J]. NERVENARZT, 2017, 88 (11): : 1273 - 1280

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