Activation Mechanisms for Organometallic Anticancer Complexes

被引：206

作者：

Pizarro, Ana M. ^{[1
]}

Habtemariam, Abraha ^{[1
]}

Sadler, Peter J. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

MEDICINAL ORGANOMETALLIC CHEMISTRY | 2010年 / 32卷

关键词：

Medicinal Organometallics; Photoactivation; Hydrolysis; Anticancer; Titanium; Ruthenium; Osmium; Ferrocene; Tin; RUTHENIUM(II) ARENE COMPLEXES; VITRO ANTITUMOR-ACTIVITY; PROTEIN-SULFENIC ACIDS; OXALI-TITANOCENE-Y; CANCER CELL-LINES; DNA-BINDING MODES; IN-VITRO; PHASE-I; BIOORGANOMETALLIC CHEMISTRY; ANTIPROLIFERATIVE ACTIVITY;

D O I：

10.1007/978-3-642-13185-1_2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Organometallic complexes offer potential for design as anticancer drugs. They can act as inert scaffolds and specifically inhibit enzymes such as kinases, or as pro-drugs which undergo activation by various mechanisms. The activation of metallocenes, arene, alkyl or aryl complexes by hydrolysis, and metal- or ligand-based redox reactions is discussed.

引用

页码：21 / 56

页数：36

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