Current State of the Art in the Adjuvant Systemic Treatment of Premenopausal Patients With Early Breast Cancer

被引：5

作者：

Parisi, Francesca ^{[1
,2
]}

Razeti, Maria Grazia ^{[1
,2
]}

Blondeaux, Eva ^{[2
,3
]}

Arecco, Luca ^{[1
,2
]}

Perachino, Marta ^{[1
,2
]}

Tagliamento, Marco ^{[2
,3
]}

Levaggi, Alessia ^{[1
]}

Fregatti, Piero ^{[4
,5
]}

Poggio, Francesca ^{[3
]}

Lambertini, Matteo ^{[1
,2
]}

机构：

[1] IRCCS Osped Policlin San Martino, Dept Med Oncol, UOC Clin Oncol Med, Genoa, Italy

[2] Univ Genoa, Sch Med, Dept Internal Med & Med Specialties DiMI, Genoa, Italy

[3] IRCCS Osped Policlin San Martino, Dept Med Oncol, UO Oncol Med 2, Genoa, Italy

[4] IRCCS Osped Policlin San Martino, UOC Clin Chirurg Senol, Genoa, Italy

[5] Univ Genoa, Sch Med, Dept Integrated Diagnost Surg Sci, Genoa, Italy

来源：

CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2020年 / 14卷

关键词：

Breast cancer; premenopausal; adjuvant; BRCA; survivorship; OVARIAN-FUNCTION SUPPRESSION; INTERNATIONAL CONSENSUS GUIDELINES; DOCETAXEL PLUS CYCLOPHOSPHAMIDE; CHEMOTHERAPY-INDUCED AMENORRHEA; DOSE-DENSE CHEMOTHERAPY; YOUNG-WOMEN; ENDOCRINE THERAPY; REPORTED OUTCOMES; PHASE-III; DOUBLE-BLIND;

D O I：

10.1177/1179554920931816

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most frequent malignancy diagnosed in premenopausal women. In this age group, breast tumors tend to be diagnosed at more advanced stages and to harbor more aggressive biological features. In addition, specific age-related issues including genetic counseling, fertility preservation, impact on social and couple relationships, working life. and management of long-term side effects should be considered highly relevant when managing early breast cancer in premenopausal women. Therefore, the care of these patients is particularly complex and a multidisciplinary approach is mandatory. The present review summarizes the current state of art in the adjuvant systemic treatment of premenopausal women with early breast cancer focusing on the optimal chemotherapy. endocrine therapy, and targeted therapy approaches in this specific patient population.

引用

页数：10

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