Combined directed ortho-metalation, remote metalation, and Stille cross-coupling strategies.: Concise stereoselective synthesis of polysubstituted 9H-fluoren-9-ones

被引：15
|
作者：
Castanet, Anne-Sophie [1 ,2 ]
Tilly, David [1 ,2 ]
Veron, Jean-Baptiste [1 ,2 ]
Samanta, Subhendu S. [1 ,2 ,3 ]
De, Asish [3 ]
Ganguly, Tapan [3 ]
Mortier, Jacques [1 ,2 ]
机构：
[1] Univ Maine, F-72085 Le Mans 9, France
[2] CNRS, UMR 6011, Unite Chim Organ Mol & Macromol, Fac Sci, F-72085 Le Mans 9, France
[3] Indian Assoc Cultivat Sci, Kolkata 700032, India
来源：
TETRAHEDRON | 2008年 / 64卷 / 15期
关键词：
ortho and remote metalations; Stille reaction; benzoic acids;
D O I：
10.1016/j.tet.2008.01.122
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The new sequential stercoselective synthesis of diversely substituted 9H-fluoren-9-ones by ortho-lithiation/Bu3SnCl quench of unprotected benzoic acids followed by Stille cross-coupling reaction and remote metalation is reported. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3331 / 3336
页数：6
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