Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/-Cyclodextrin Fibers as an Antimicrobial Wound Dressing

被引：61
|
作者：
Liu, Yaowen [1 ,2 ]
Liang, Xue [1 ]
Zhang, Rong [1 ]
Lan, Wenting [1 ]
Qin, Wen [1 ]
机构：
[1] Sichuan Agr Univ, Coll Food Sci, Yaan 625014, Peoples R China
[2] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
来源：
POLYMERS | 2017年 / 9卷 / 10期
基金：
中国国家自然科学基金;
关键词：
electrospinning; polylactic acid (PLA); cinnamaldehyde; -cyclodextrins; ESSENTIAL OIL; CHITOSAN NANOPARTICLES; PHYSICOCHEMICAL CHARACTERIZATION; ANTIFUNGAL PROPERTIES; SILVER NANOPARTICLES; INCLUSION COMPLEX; CINNAMALDEHYDE; ANTIBACTERIAL; NANOFIBERS; ENCAPSULATION;
D O I：
10.3390/polym9100464
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Cinnamaldehyde (CA) was successfully encapsulated in -cyclodextrin (-CD), and polylactic acid (PLA)-based composite fibers were prepared by incorporating CA/-CD via electrospinning. Morphological, structural, spectral, and antibacterial properties of different weight ratios of PLA:-CD/CA (88:12, 94:6, 97:3, and 98.5:1.5) and PLA/CA/-CD fibers were investigated. PLA and CA/-CD were incorporated by mixing of CA/-CD inclusions to enhance the viscosity of the mixed solution. The mechanical properties and hydrophilicity of nanofibers were improved following the addition of CA/-CD. Moreover, CA/-CD improved the antibacterial activities of the mixture against Escherichia coli and Staphylococcus aureus. PLA/CA/-CD-3 exhibited excellent antibacterial effects and low cytotoxicity. Thus, our study showed that PLA/CA/-CD fibers may have applications as wound dressing materials and for use in other biomedical applications.
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页数：14
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