Genome-wide CNV analysis revealed variants associated with growth traits in African indigenous goats

被引：18
|
作者：
Liu, Mei [1 ,2 ]
Woodward-Greene, Jennifer [1 ]
Kang, Xiaolong [1 ,3 ]
Pan, Michael G. [1 ]
Rosen, Benjamin [1 ]
Van Tassell, Curtis P. [1 ]
Chen, Hong [2 ]
Liu, George E. [1 ]
机构：
[1] USDA ARS, Anim Genom & Improvement Lab, BARC, Beltsville, MD 20705 USA
[2] Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Agr Mol Biol, Yangling 712100, Shaanxi, Peoples R China
[3] Ningxia Univ, Coll Agr, Ningxia 750021, Peoples R China
来源：
GENOMICS | 2020年 / 112卷 / 02期
基金：
美国食品与农业研究所;
关键词：
Copy number variation; Association; Body size; African goats; COPY NUMBER VARIATION; DOMAINS; GENE;
D O I：
10.1016/j.ygeno.2019.08.018
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Using the CaprineSNP50 data generated by the AGIN consortium, we detected common CNVs in 126 samples from four African indigenous goat breeds. A total of 30 CNVs ranging from 30,237 bp to 4,910,757 bp were identified. These CNVs were then associated with six growth traits by a linear regression analysis. Three significant associations were identified between two CNVs and two body traits after false discovery rate (FDR) correction (P < .05). One of them (CNV27) was significantly associated with both chest width and width of pin bones. It overlaps the SNX29 gene, the Gene Ontology (GO) annotations of which indicate CNV27 could be a potential functional candidate for meat production, health and reproduction traits. To our knowledge, this study is the first CNV-based association test of growth traits using SNP chip data in African meat goats.
引用
收藏
页码：1477 / 1480
页数：4
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