Dynamics of double strand breaks and chromosomal translocations

被引：38

作者：

Iarovaia, Olga V. ^{[1
,3
]}

Rubtsov, Mikhail ^{[3
,4
]}

Ioudinkova, Elena ^{[1
,3
]}

Tsfasman, Tatiana ^{[2
,3
]}

Razin, Sergey V. ^{[1
,3
,4
]}

Vassetzky, Yegor S. ^{[2
,3
,4
]}

机构：

[1] Russian Acad Sci, Inst Gene Biol, Moscow 117334, Russia

[2] Univ Paris 11, CNRS, Inst Cancerol Gustave Roussy, UMR8126, F-94805 Villejuif, France

[3] LIA1066 Lab Francorusse Rech Oncol, Villejuif, France

[4] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119992, Russia

来源：

MOLECULAR CANCER | 2014年 / 13卷

基金：

俄罗斯科学基金会;

关键词：

TOPOISOMERASE-II-BETA; THERAPY-RELATED LEUKEMIA; HOMOLOGOUS RECOMBINATION; CHROMATIN DYNAMICS; GENOMIC INSTABILITY; SECONDARY LEUKEMIAS; GENE-EXPRESSION; LIVING CELLS; DNA CLEAVAGE; REPAIR;

D O I：

10.1186/1476-4598-13-249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the mechanisms of generation, mobility and repair of DSBs and stress the importance of the nuclear organization in this process.

引用

页数：10

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