APRIL INDUCES A NOVEL SUBSET OF IGA plus REGULATORY B CELLS THAT SUPPRESS INFLAMMATION THROUGH THE EXPRESSION OF IL-10 AND PD-L1

被引:0
|
作者
Fehres, C. [1 ]
van Uden, N. [1 ]
Yeremenko, N. [1 ]
Fernandez, L. [2 ]
Salinas, G. Franco [1 ]
van Duivenvoorde, L. [1 ]
Huard, B. [3 ]
Morel, J. [4 ]
Spits, H. [5 ,6 ]
Hahne, M. [2 ]
Baeten, D. [1 ]
机构
[1] Acad Med Ctr, Clin Immunol & Rheumatol & Expt Immunol, Amsterdam, Netherlands
[2] Univ Montpellier, Inst Genet Mol Montpellier, Montpellier, France
[3] Univ Grenoble Alpes, Inst Adv Biosci, Grenoble, France
[4] Univ Montpellier, Dept Rheumatol, Montpellier, France
[5] Acad Med Ctr, Amsterdam, Netherlands
[6] AIMM Therapeut, Amsterdam, Netherlands
关键词
D O I
10.1136/annrheumdis-2018-eular.3715
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OP0205
引用
收藏
页码:151 / 152
页数:2
相关论文
共 50 条
  • [1] APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1
    Fehres, Cynthia M.
    van Uden, Nathalie O.
    Yeremenko, Nataliya G.
    Fernandez, Leticia
    Salinas, Gabriela Franco
    van Duivenvoorde, Leonie M.
    Huard, Bertrand
    Morel, Jacques
    Spits, Hergen
    Hahne, Michael
    Baeten, Dominique L. P.
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [2] Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis
    Schaut, Robert G.
    Lamb, Ian M.
    Toepp, Angela J.
    Scott, Benjamin
    Mendes-Aguiar, Carolina O.
    Coutinho, Jose F. V.
    Jeronimo, Selma M. B.
    Wilson, Mary E.
    Harty, John T.
    Waldschmidt, Thomas J.
    Petersen, Christine A.
    JOURNAL OF IMMUNOLOGY, 2016, 196 (10): : 4100 - 4109
  • [3] BIP induces mice CD19hi regulatory B cells producing IL-10 and highly expressing PD-L1, FasL
    Tang, Youfa
    Jiang, Qing
    Ou, Yanghui
    Zhang, Fan
    Qing, Kai
    Sun, Yuanli
    Lu, Wenjie
    Zhu, Huifen
    Gong, Feili
    Lei, Ping
    Shen, Guanxin
    MOLECULAR IMMUNOLOGY, 2016, 69 : 44 - 51
  • [4] Salmonella induces PD-L1 expression in B cells
    Lopez-Medina, Marcela
    Perez-Lopez, Araceli
    Alpuche-Aranda, Celia
    Ortiz-Navarrete, Vianney
    IMMUNOLOGY LETTERS, 2015, 167 (02) : 131 - 140
  • [5] Relationship between IL-10 and PD-L1 in esophageal carcinoma tissues and IL-10 down-regulates PD-L1 expression via Met signaling pathway
    Qian, Qian
    Wu, Changping
    Chen, Jianping
    Wang, Weibing
    JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2020, 11 (02) : 337 - +
  • [6] PPARγ induces PD-L1 expression in MSS plus colorectal cancer cells
    Gutting, Tobias
    Hauber, Veronika
    Pahl, Jens
    Klapproth, Kay
    Wu, Wenyue
    Dobrota, Ioana
    Herweck, Frank
    Reichling, Juliane
    Helm, Laura
    Schroeder, Torsten
    Li, Beifang
    Weidner, Philip
    Zhan, Tianzuo
    Eckardt, Maximilian
    Betge, Johannes
    Belle, Sebastian
    Sticht, Carsten
    Gaiser, Timo
    Boutros, Michael
    Ebert, Matthias P. A.
    Cerwenka, Adelheid
    Burgermeister, Elke
    ONCOIMMUNOLOGY, 2021, 10 (01):
  • [7] IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
    Brooks, David G.
    Ha, Sang-Jun
    Elsaesser, Heidi
    Sharpe, Arlene H.
    Freeman, Gordon J.
    Oldstone, Michael B. A.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (51) : 20428 - 20433
  • [8] IL-27 induces the expression of IDO and PD-L1 in human cancer cells
    Carbotti, Grazia
    Barisione, Gaia
    Airoldi, Irma
    Mezzanzanica, Delia
    Bagnoli, Marina
    Ferrero, Simone
    Petretto, Andrea
    Fabbi, Marina
    Ferrini, Silvano
    ONCOTARGET, 2015, 6 (41) : 43267 - 43280
  • [9] Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10
    Rodriguez-Garcia, Marta
    Porichis, Filippos
    de Jong, Olivier G.
    Levi, Karen
    Diefenbach, Thomas J.
    Lifson, Jeffrey D.
    Freeman, Gordon J.
    Walker, Bruce D.
    Kaufmann, Daniel E.
    Kavanagh, Daniel G.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2011, 89 (04) : 507 - 515
  • [10] TLR7-elicited regulatory B cells use IL-10 to suppress airway inflammation through induction of CD4+FoxP3+ T cells
    Khan, A. R.
    Amu, S.
    Saunders, S. P.
    Weaver, C.
    Sparwasser, T.
    Fallon, P. G.
    IMMUNOLOGY, 2013, 140 : 61 - 61