Aging, Persistent Viral Infections, and Immunosenescence: Can Exercise "Make Space''?

被引：123

作者：

Simpson, Richard J. ^{[1
]}

机构：

[1] Univ Houston, Dept Hlth & Human Performance, Lab Integrated Physiol, Houston, TX 77204 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2011年 / 39卷 / 01期

关键词：

immune risk profile; cytomegalovirus; lymphocyte apoptosis; T cell; immunology; PERIPHERAL-BLOOD COMPARTMENT; SENESCENT T-LYMPHOCYTES; HIGH-INTENSITY EXERCISE; CYTOMEGALOVIRUS-INFECTION; REPLICATIVE SENESCENCE; MEMORY CELLS; MOBILIZATION; APOPTOSIS; EXPRESSION; LATENT;

D O I：

10.1097/JES.0b013e318201f39d

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

SIMPSON, R.J. Aging, persistent viral infections, and immunosenescence: can exercise "make space''? Exerc. Sport Sci. Rev., Vol. 39, No. 1, pp. 23-33, 2011. Overcrowding the immune space with excess clones of viral-specific T cells causes the naive T-cell repertoire to shrink, which increases infection susceptibility to novel pathogens. Physical exercise preferentially mobilizes senescent T cells from the peripheral tissues into the blood, which might facilitate their subsequent apoptosis and create "vacant space'' for newly functional T cells to occupy and expand the naive T-cell repertoire.

引用

页码：23 / 33

页数：11

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