An mPOA-ARCAgRP pathway modulates cold-evoked eating behavior

被引：15

作者：

Yang, Shuo ^{[1
,2
]}

Tan, Yu Lin ^{[3
]}

Wu, Xiaohua ^{[1
,2
]}

Wang, Jingjie ^{[1
,2
]}

Sun, Jingjing ^{[1
,2
]}

Liu, Anqi ^{[1
,2
]}

Gan, Linhua ^{[1
,2
]}

Shen, Bo ^{[5
,6
]}

Zhang, Xiaocui ^{[7
]}

Fu, Yu ^{[3
]}

Huang, Ju ^{[1
,2
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Ctr Brain Sci, Shanghai Childrens Med Ctr, Sch Med, Shanghai 200127, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Dept Anat & Physiol, Shanghai 200025, Peoples R China

[3] Singapore Bioimaging Consortium, 11 Biopolis Way, Singapore 138667, Singapore

[4] Shanghai Res Ctr Brain Sci & Brain Inspired Intel, Shanghai 201210, Peoples R China

[5] Fudan Univ, Huashan Hosp, Dept Neurol, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China

[6] Fudan Univ, Huashan Hosp, Inst Neurol, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Med, Basic Med Fac, Core Facil Basic Med Sci, Shanghai 200025, Peoples R China

来源：

CELL REPORTS | 2021年 / 36卷 / 06期

关键词：

PREOPTIC AREA; NEURONS; FOOD; HYPOTHALAMUS; TEMPERATURE; CIRCUIT;

D O I：

10.1016/j.celrep.2021.109502

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Enhanced appetite occurs as a means of behavioral thermoregulation at low temperature. Neural circuitry mediating this crosstalk between behavioral thermoregulation and energy homeostasis remains to be elucidated. We find that the hypothalamic orexigenic agouti-related neuropeptide (AgRP) neurons in the arcuate nucleus (ARC) are profoundly activated by cold exposure. The calcium signals in ARC(AgRP) neurons display an immediate-response pattern in response to cold stimulation. Cold-responsive neurons in the medial preoptic area (mPOA) make excitatory synapses onto ARC(AgRP) neurons. Inhibition of either ARC(AgRP) neurons or ARCprojecting mPOA neurons attenuates cold-evoked feeding, while activation of the mPOA-to-ARC projection increases food intake. These findings reveal an mPOA-ARC AgRP neural pathway that modulates cold-evoked feeding behavior.

引用

页数：14

共 1 条

[1] Central corticotropin releasing hormone receptor 2 may participate in sex differential regulation of cold-evoked eating behavior
Zhou, Ying
Zhu, Shuqing
Ye, Shangwu
Ye, Ziyuan
Chen, Wenxi
Li, Jieshan
Shu, Gang
Wang, Songbo
Zhu, Canjun
Wu, Ruifan
Jiang, Qingyan
Wang, Lina
NEUROSCIENCE, 2025, 566 : 169 - 176

← 1 →