Metal-based nanoparticles as radio-sensitizer in gastric cancer therapy

Radiation therapy is a type of cancer treatment modalities which uses high energy ionizing radiation to kill or control cancer cells. To date, many efforts have been made to dose escalation in tumor site and reduction of radiation toxicity in normal tissue to improve therapeutic efficacy. While recent advances in radiation therapy techniques and also introducing new medical imaging modalities have brought grate promise to achieve this goal, tumor radioresistance remains a significant clinical concern. It seems that nanotechnology may, by rapid advances, be a good candidate to be used to overcome this problem. In this regard many studies have evaluated potential use of nanoparticles as radiosensitizers agents in different cancer radiotherapy. This article sets out to review the developments on metal-based nanoparticles as radiosensitizers in gastric cancer treatment.