Characterization of a new HLA-B allele, HLA-B*5312, and re-evaluation of the published sequences of the untranslated regions of HLA-B*35 and HLA-B*53

被引：5
|
作者：
Heinold, A. [1 ]
Bauer, M. [1 ]
Scherer, S. [1 ]
Opelz, G. [1 ]
Tran, T. H. [1 ]
机构：
[1] Heidelberg Univ, Inst Immunol, Dept Transplantat Immunol, D-69120 Heidelberg, Germany
来源：
TISSUE ANTIGENS | 2007年 / 70卷 / 04期
关键词：
HLA-B*5312; HLA-B*350101; HLA-B*530101; human leukocyte antigen; polymerase chain reaction with sequence-specific primers; sequence-based typing;
D O I：
10.1111/j.1399-0039.2007.00900.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We report a novel human leukocyte antigen (HLA)-B allele, HLA-B*5312. Compared with HLA-B*530101, there is one silent substitution at nucleotide 438 and two non-synonymous substitutions at nucleotides 431 and 440, causing a change of the amino acid sequence (Asn -> Ser at codon 77 and Ile -> Thr at codon 80, respectively) within the Bw4 epitope. In contrast to the published sequences (IMGT/HLA Database, version 2.16.0, January 2007), we found that HLA-B*530101 had a C instead of a T at nucleotide -221, whereas HLA-B*350101 had a C instead of an A at nucleotide 2992. According to our sequencing results, HLA-B*5312 resembles HLA-B*350101 regarding its sequence of the untranslated regions. HLA-B*5312 may have been the result of a double crossing over event during which HLA-B*350101 adopted a Bw4 motif.
引用
收藏
页码：319 / 323
页数：5
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