Long-Term Outcomes following Repair or Replacement in Degenerative Mitral Valve Disease

Background: We studied whether mitral valvuloplasty (MVP) was superior to mitral valve replacement (MVR) in patients with degenerative mitral regurgitation (MR), and analyzed the independent risk factors for survival and reoperation. Methods: 326 patients with degenerative MR underwent MVP (n = 241), mitral valve replacement (MVR) (n = 78) or emergent MVR due to failure of repair (EMVR). Clinical data were analyzed retrospectively. Results: Thirty-day mortality was lower after MVP (2.5%) compared to MVR (9.0%) (p < 0.05). Late survival at 1 and 5 years in the MVP group was 94.4% and 84.3% versus 80.4% and 64.6% in the MVR group (p < 0.05), respectively. After ad-justing the baseline characteristics by the propensity score method, a significant survival benefit was found for patients who underwent MVP. Multivariable analysis showed that MVR was an independent predictor of thirty-day mortality and survival. There was no significant difference in thirty-day mortality and survival between the EMVR and MVR groups. The need for reoperation was not significantly different between the MVP and MVR groups. In the MVP group, the risk factors for survival and reoperation were identified. Conclusions: MVP is superior to MVR for the treatment of degenerative MR despite the impact of repair failure. Age less than 60 years, ring size to body surface area greater than 19.0, absence of a prosthetic ring and residual MR at the end of surgery (>= 1/4) reduce the durability of MVP.