Resistant Hypertension and Sleep Apnea: Pathophysiologic Insights and Strategic Management

被引：11
|
作者：
Williams, Stephen K. [1 ,2 ,3 ]
Ravenell, Joseph [1 ]
Jean-Louis, Girardin [4 ,5 ]
Zizi, Ferdinand [4 ,5 ]
Underberg, James A. [6 ]
McFarlane, Samy I. [4 ,7 ,8 ]
Ogedegbe, Gbenga [1 ]
机构：
[1] New York Univ, Sch Med, Ctr Healthful Behav Change, Div Gen Internal Med, New York, NY 10010 USA
[2] Cornell Univ, Weill Med Coll, Ctr Complementary & Integrat Med, New York, NY 10021 USA
[3] Cornell Univ, Weill Med Coll, Div Gen Internal Med, New York, NY 10021 USA
[4] Suny Downstate Med Ctr, Brooklyn Hlth Dispar Ctr, Dept Med, Brooklyn, NY 11203 USA
[5] Suny Downstate Med Ctr, Sleep Disorders Ctr, Dept Med, Brooklyn, NY 11203 USA
[6] New York Univ, Sch Med, Ctr Cardiovasc Prevent, Div Gen Internal Med, New York, NY 10010 USA
[7] SUNY, Downstate Med Ctr, Div Endocrinol Diabet & Hypertens, Dept Med, Brooklyn, NY 11203 USA
[8] Kings Cty Hosp Ctr, Brooklyn, NY 11203 USA
来源：
CURRENT DIABETES REPORTS | 2011年 / 11卷 / 01期
关键词：
Sleep-disordered breathing; Sleep apnea; Drug-resistant hypertension; Obesity; Diuretics; Continuous positive airway pressure; POSITIVE AIRWAY PRESSURE; PROFESSIONAL-EDUCATION-COMMITTEE; AMBULATORY BLOOD-PRESSURE; INDEPENDENT RISK-FACTOR; SCIENTIFIC STATEMENT; BREATHING DISORDER; HIGH PREVALENCE; ASSOCIATION; HYPOXIA; BP;
D O I：
10.1007/s11892-010-0161-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Resistant hypertension is common among adults with hypertension affecting up to 30% of patients. The treatment of resistant hypertension is important because suboptimal blood pressure control is the leading preventable cause of death worldwide. A frequent comorbid condition in patients with resistant hypertension is obstructive sleep apnea. The pathophysiology of sleep apnea-associated hypertension is characterized by sustained adrenergic activation and volume retention often posing treatment challenges in patients with resistant hypertension. This review will address some of the epidemiologic data associating apnea with the pathogenesis of resistant hypertension. Diagnosis and management of apnea and its associated hypertension will also be considered.
引用
收藏
页码：64 / 69
页数：6
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