Age-Related Changes of the Oligodendrocytes in Rat Subcortical White Matter

被引：15

作者：

Chen, Lin ^{[1
,2
]}

Lu, Wei ^{[1
,2
]}

Yang, Zhengwei ^{[3
]}

Yang, Shu ^{[4
]}

Li, Chen ^{[4
]}

Shi, Xiaoyan ^{[4
]}

Tang, Yong ^{[1
,2
]}

机构：

[1] Chongqing Med Univ, Dept Histol & Embryol, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Lab Stem Cell & Tissue Engn, Chongqing 400016, Peoples R China

[3] N Sichuan Med Coll, Morphometr Res Lab, Nanchong 637007, Peoples R China

[4] Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2011年 / 294卷 / 03期

关键词：

CNPase(+) cell; subcortical white matter; rat; aging; optical fractionator; PREFRONTAL CORTEX; COGNITIVE DECLINE; NERVE-FIBERS; GLIAL-CELLS; NUMBER; MYELIN; DEGENERATION; HIPPOCAMPUS; STEREOLOGY; EFFICIENCY;

D O I：

10.1002/ar.21332

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The age-related changes, of the oligodendrocytes in rat subcortical white matter, were investigated in this study. The oligodendrocytes in subcortical white matter were labeled with anti-2',3'-cyclic nucleotide 3'-phosphodiesterase antibody (anti-CNPase antibody, a specific marker of oligodendrocytes). The total number of CNPase(+) cells was estimated with an unbiased stereological technique, the optical fractionator. In this study, we found that the total number of CNPase(+) cells in the young male rats and aged male rats was 14.4 +/- 1.2 x 10(6) and 9.0 +/- 1.0 x 10(6), respectively. The total number of the CNPase(+) cells in the subcortical white matter of aged rats was significantly decreased by 37.5% when compared to young male rats. This study demonstrated that there was an aged-related decrease of the oligodendrocytes in subcortical white matter. Anat Rec, 294:487-493, 2011. (C) 2011 Wiley-Liss, Inc.

引用

页码：487 / 493

页数：7

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