Enantiomeric separation of some amino acids and derivatives by capillary electrophoresis with 18-crown-6-tetracarboxylic acid as chiral selector

被引：0
|
作者：
Verleysen, K [1 ]
Sandra, P [1 ]
机构：
[1] State Univ Ghent, Dept Organ Chem, B-9000 Ghent, Belgium
来源：
JOURNAL OF MICROCOLUMN SEPARATIONS | 1999年 / 11卷 / 01期
关键词：
capillary electrophoresis; enantioselective separations; 18-crown-6-tetracarboxylic acid (18C6H(4)); amino acids and derivatives;
D O I：
10.1002/(SICI)1520-667X(1999)11:1<37::AID-MCS5>3.0.CO;2-X
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A number of amino acids and derivatives, bought or synthesized, were analyzed by capillary electrophoresis (CE:) with optical active 18-crown-6-tetracarboxylic acid (18C6H(4)) as chiral selector. Besides the primary interaction: i.e., inclusion of the protonated primary amino function in the crown ether cavity, a second interaction mechanism between the substituents on the racemates and the carboxylic acid functions on the crown ether to enhance or suppress enantioselectivity. In certain cases, very high resolutions (R-s > 5) were noted, e.g., R-s 30 for serine benzyl ester. (C) 1999 John Wiley & Sons, Inc.
引用
收藏
页码：37 / 43
页数：7
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