A clean, simple and efficient synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2-h]quinolin-2-yl]-(4-chlorophenyl)methanones

被引：0
|
作者：
Salari, Maryam [1 ]
Hassanabadi, Alireza [2 ]
Mosslemin, Mohammad H. [1 ]
机构：
[1] Islamic Azad Univ, Yazd Branch, Dept Chem, Yazd, Iran
[2] Islamic Azad Univ, Zahedan Branch, Dept Chem, Zahedan, Iran
来源：
JOURNAL OF CHEMICAL RESEARCH | 2017年 / 07期
关键词：
8-hydroxyquinoline; choline hydroxide; green chemistry; multi-component reaction; aromatic aldehydes; 4-chlorophenacyl bromide; 1,3-DICARBONYL COMPOUNDS; DIASTEREOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; DIPOLAR CYCLOADDITION; DIHYDROFURANS; DERIVATIVES; REGIO;
D O I：
10.3184/174751917X14967701767058
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a green and efficient method for the synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2-h]quinolin-2-yl]-(4-chlorophenyl)methanones from the condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 8-hydroxyquinoline and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water at reflux conditions. This new protocol employing choline hydroxide, which is a green and inexpensive catalyst, offers advantages such as mild reaction conditions, short reaction time, high yields and does not involve any hazardous solvent. Therefore, this procedure can be classified as green chemistry.
引用
收藏
页码：380 / 383
页数：4
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