Isolation of (-)(2S)-5,6,7,3',5'-pentahydroxyflavanone-7-O--D-glucopyranoside, from Lippia graveolens HBK var. berlandieri Schauer, a new anti-inflammatory and cytotoxic flavanone

被引：9

作者：

Gonzalez-Guereca, M. C. ^{[2
]}

Soto-Hernandez, M. ^{[3
]}

Martinez-Vazquez, M. ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[2] Inst Politecn Nacl, Durango 34220, Dgo, Mexico

[3] Colegio Postgrad, Texcoco, Edo De Mexico, Mexico

来源：

NATURAL PRODUCT RESEARCH | 2010年 / 24卷 / 16期

关键词：

Lippia graveolens; flavanone; anti-inflammatory; cytotoxic; FLAVONOIDS; GLYCOSIDES;

D O I：

10.1080/14786419.2010.488234

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new flavanone glycoside, (-)(2S)-5,6,7,3',5'-pentahydroxyflavanone-7-O--D-glucopyranoside (1), was isolated from the stems of Lippia graveolens H.B.K. (Verbenaceae). The structure of 1 was elucidated based on spectral analysis and chemical transformations. The treatment of 1 with acetic anhydride and pyridine afforded the corresponding per-acetylated derivative 2, while an acid hydrolysis reaction of 1 afforded a 5,6,7,3',5'-pentahydroxy flavanone (3). Additionally, the anti-inflammatory and cytotoxic activities of 1, 2 and 3 were determined.

引用

页码：1528 / 1536

页数：9