Telomere length inheritance and aging

被引：44
|
作者：
Kappei, Dennis [1 ]
Londono-Vallejo, J. Arturo [1 ]
机构：
[1] UPMC, CNRS, Inst Curie, UMR7147,Telomeres & Canc Lab, F-75248 Paris 05, France
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2008年 / 129卷 / 1-2期
关键词：
telomere length; aging; premature aging; longevity; genetic factors; heredity; telomerase; proliferation potential;
D O I：
10.1016/j.mad.2007.10.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Telomere shortening accompanies human aging, and premature aging syndromes are often associated with short telomeres. These two observations are central to the hypothesis that telomere length directly influences longevity. If true, genetically determined mechanisms of telomere length homeostasis should significantly contribute to variations of longevity in the human population. On the other hand, telomere shortening is also observed in the course of many aging-associated disorders but determining whether it is a cause or a consequence is not an easy task. Here, we review the most relevant experimental and descriptive data relating telomere length, as a quantitative trait, to aging and longevity. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：17 / 26
页数：10
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