Rethinking the role of ceruloplasmin in brain iron metabolism

被引:75
|
作者
Qian, ZM [1 ]
Ke, Y [1 ]
机构
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Lab Brain Iron Metab, Kowloon, Hong Kong, Peoples R China
关键词
ceruloplasmin; brain iron metabolism; iron efflux and influx; aceruloplasminemia; neurodegenerative diseases;
D O I
10.1016/S0165-0173(01)00056-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
For more than three decades, it has been widely accepted that ceruloplasmin plays an important role in iron efflux from mammalian cells, including brain cells, via the activity of ferroxidase. However, in tight of recent findings, this view might not be completely accurate and the role of ceruloplasmin in brain iron metabolism may need to be re-evaluated. Based on recent studies, we propose in this article that the role of ceruloplasmin in iron uptake by brain neuronal cells might be more important than its role in iron release from the cells. A possible explanation of why the absence of ceruloplasmin induces excessive iron accumulation in neurons in aceruloplasminemia (ceruloplasmin gene mutations) was also discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:287 / 294
页数:8
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