Mycobacterium tuberculosis serine/threonine kinases PknB, PknD, PknE, and PknF phosphorylate multiple FHA domains

被引：72
|
作者：
Grundner, C [1 ]
Gay, LM [1 ]
Alber, T [1 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
PROTEIN SCIENCE | 2005年 / 14卷 / 07期
关键词：
FHA domain; protein phosphorylation; serine/threonine protein kinase; signaling;
D O I：
10.1110/ps.051413405
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The physiologic roles and the substrates of the Mycobacterium tuberculosis (Mtb) serine/threonine kinases are largely unknown. Here, we report six novel interactions of PknB, PknD, PknE, and PknF with the Forkhead-Associated (FHA) domains of Rv0020c and the putative ABC transporter Rv1747. Purified PknB and PknF kinase domains phosphorylated multiple FHA-domain proteins in vitro. Although they remain to be verified in vivo, these reactions suggest a web of interactions between STPKs and FHA domains.
引用
收藏
页码：1918 / 1921
页数：4
相关论文
共 33 条
  • [1] Characterization of the phosphorylation sites of Mycobacterium tuberculosis serine/threonine protein kinases, PknA, PknD, PknE, and PknH by mass spectrometry
    Molle, Virginie
    Zanella-Cleon, Isabelle
    Robin, Jean-Philippe
    Mallejac, Souen
    Cozzone, Alain J.
    Becchi, Michel
    PROTEOMICS, 2006, 6 (13) : 3754 - 3766
  • [2] Specificity and Reactivity of Mycobacterium tuberculosis Serine/Threonine Kinases PknG and PknB
    Burastero, Osvaldo
    Cabrera, Marisol
    Lopez, Elias D.
    Defelipe, Lucas A.
    Pablo Arcon, Juan
    Duran, Rosario
    Marti, Marcelo A.
    Turjanski, Adrian G.
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 62 (07) : 1723 - 1733
  • [3] Serine/threonine protein kinases PknF and PknG of Mycobacterium tuberculosis:: characterization and localization
    Koul, A
    Choidas, A
    Tyagi, AK
    Drlica, K
    Singh, Y
    Ullrich, A
    MICROBIOLOGY-SGM, 2001, 147 : 2307 - 2314
  • [4] pknE, a serine/threonine kinase of Mycobacterium tuberculosis modulates multiple apoptotic paradigms
    Kumar, Dinesh
    Narayanan, Sujatha
    INFECTION GENETICS AND EVOLUTION, 2012, 12 (04) : 737 - 747
  • [5] Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB
    Chopra, P
    Singh, B
    Singh, R
    Vohra, R
    Koul, A
    Meena, LS
    Koduri, H
    Ghildiyal, M
    Deol, P
    Das, TK
    Tyagi, AK
    Singh, Y
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 311 (01) : 112 - 120
  • [6] The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape
    Kang, CM
    Abbott, DW
    Park, ST
    Dascher, CC
    Cantley, LC
    Husson, RN
    GENES & DEVELOPMENT, 2005, 19 (14) : 1692 - 1704
  • [7] Mycobacterium tuberculosis Serine/Threonine Protein Kinases
    Prisic, Sladjana
    Husson, Robert N.
    MICROBIOLOGY SPECTRUM, 2014, 2 (05):
  • [8] Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB
    Av-Gay, Y
    Jamil, S
    Drews, SJ
    INFECTION AND IMMUNITY, 1999, 67 (11) : 5676 - 5682
  • [9] The Mycobacterium bovis homologous protein of the Mycobacterium tuberculosis serine/threonine protein kinase Mbk (PknD) is truncated
    Peirs, P
    Parmentier, B
    De Wit, L
    Content, J
    FEMS MICROBIOLOGY LETTERS, 2000, 188 (02) : 135 - 139
  • [10] Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis
    Ortiz-Lombardía, M
    Pompeo, F
    Boitel, B
    Alzari, PM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (15) : 13094 - 13100
1234