Branched versus fenestrated endografts for endovascular repair of aortic arch lesions

被引:119
|
作者
Tsilimparis, Nikolaos [1 ]
Debus, E. Sebastian [1 ]
von Kodolitsch, Yskert [2 ]
Wipper, Sabine [1 ]
Rohlffs, Fiona [1 ]
Detter, Christian [3 ]
Roeder, Blayne [4 ]
Koelbel, Tilo [1 ]
机构
[1] Univ Heart Ctr, German Aort Ctr Hamburg, Dept Vasc Med, Hamburg, Germany
[2] Univ Heart Ctr, German Aort Ctr Hamburg, Dept Cardiol, Hamburg, Germany
[3] Univ Heart Ctr, German Aort Ctr Hamburg, Dept Cardiac Surg, Hamburg, Germany
[4] Cook Med, Bloomington, IN USA
关键词
STENT-GRAFT; DISSECTION; ANEURYSM; SURGERY;
D O I
10.1016/j.jvs.2016.03.410
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objective: Endovascular repair of the aortic arch represents a formidable challenge because of aortic diameter, angulation, elasticity, and greater distance to the femoral access vessels. Whereas both fenestrated and branched endografts have been customized to accommodate complex pathologic processes of the arch, no data comparing the techniques are available. The aim of this study was to compare the outcomes of custom-made fenestrated vs branched thoracic endovascular aortic repair (fTEVAR vs bTEVAR). Methods: This was a single-center, retrospective comparative study of all consecutive patients treated with fTEVAR and bTEVAR for aortic arch diseases. All patients were considered unsuitable for open surgical therapy and treated with customized stent grafts (Cook Medical, Bloomington, Ind). Results: Within 42 months, 29 patients under went fTEVAR and bTEVAR(66 +/- 9 years; nine female patients). The fTEVAR patients (n =15) had no differences in comorbidities compared with the bTEVAR patients (n =14). Dissection or post-dissection aneurysm was the indication in 6 of 15 fTEVARs and 5 of 14 bTEVARs (40% vs 36%; P =NS); the remaining procedures were performed for aneurysms. Six (40%) fTEVAR patients underwent previous cervical debranching compared with all bTEVAR patients. In all patients with bTEVAR, two arch vessels were targeted (innominate, 13; left carotid artery, 14; left subclavian artery, 1), whereas fTEVAR targeted 1.6 +/- 0.5 arch vessels (bovine trunk, 4; innominate artery, 1; left carotid artery, 10; left subclavian artery, 9). Technical success was achieved in all but one case of a fenestrated endograft that was displaced, resulting in major stroke and death of the patient. Strokes occurred in two fTEVAR patients and one bTEVAR patient (P=NS). The 30-day mortality was 20% in the fTEVAR patients (n=3) vs 0% in the bTEVAR patients (P=NS). The causes of early mortality were major stroke (n =1), access complication (n =1), and myocardial infarction (n =1). Mean follow-up was 8 (1-35) and 10 (2-22) months for fTEVAR and bTEVAR, respectively. No branch occlusions occurred, and two patients underwent coil embolization for endoleaks (P=NS). One patient was readmitted with infected branched endograft 4 months after intervention and has so far been successfully treated with aneurysm sac drainage and antibiotics. There was one late nonaneurysm-related death in each group. Conclusions: Both fTEVAR and bTEVAR are feasible for the treatment of aortic arch diseases in high-risk patients. Results are promising, although fTEVAR was associated with higher mortality in this early experience. bTEVAR was more commonly used in Ishimaru zone
引用
收藏
页码:592 / 599
页数:8
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