Association among sperm chromatin condensation, sperm DNA fragmentation and 8-OHdG in seminal plasma and semen parameters in infertile men with oligoasthenoteratozoospermia

被引：5
|
作者：
Hologlu, Dilara [1 ]
Gunes, Sezgin [1 ,2 ]
Asci, Ramazan [1 ,3 ]
Henkel, Ralf [4 ,5 ,6 ]
Guvenc, Tolga [7 ]
机构：
[1] Ondokuz Mayis Univ, Hlth Sci Inst, Dept Multidisciplinary Mol Med, Samsun, Turkey
[2] Ondokuz Mayis Univ, Fac Med, Dept Med Biol, TR-55139 Samsun, Turkey
[3] Ondokuz Mayis Univ, Fac Med, Dept Urol, Samsun, Turkey
[4] Imperial Coll London, Dept Metab Digest & Reprod, London, England
[5] Univ Western Cape, Dept Med Biosci, Bellville, South Africa
[6] Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44106 USA
[7] Ondokuz May S Univ, Fac Vet Med, Dept Pathol, Samsun, Turkey
来源：
ANDROLOGIA | 2022年 / 54卷 / 01期
关键词：
8-OHdG; chromatin condensation; OAT; semen parameters; sperm DNA fragmentation; PROTAMINE DEFICIENCY; HUMAN SPERMATOZOA; DAMAGE; FERTILITY;
D O I：
10.1111/and.14268
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
The present study aimed to investigate the clinical role of standard sperm diagnosis parameters (sperm concentration, motility, morphology) as well as aniline blue staining of histones, 8-OHdG, TUNEL assay were performed on semen samples in infertile men with oligoasthenoteratozoospermia (OAT). Thirty-two infertile and ten proven fertile men were included in the study. Chromatin condensation sperm in infertile men was significantly lower compared to the fertile men (p < 0.0001). Age, sperm concentration, morphology and motility were significantly negatively correlated with chromatin condensation (p < 0.05). However, no significant correlations among the chromatin condensation, SDF and sperm DNA damage were detected in terms of 8-OHdG concentration.
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页数：7
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