Dual targeting of CDK4 and ARK5 using a novel kinase inhibitor ON123300 is effective in vitro and in vivo in Multiple Myeloma

被引：0

作者：

Perumal, Deepak ^{[1
]}

Thirukonda, Venu ^{[2
]}

Jiang, Zewei ^{[3
]}

Leshchenko, Violetta V. ^{[1
]}

Kuo, Pei-Yu ^{[1
]}

Shahnaz, Samira ^{[4
]}

Rubel, Jennifer ^{[1
]}

Zhang, Weijia ^{[1
]}

Cho, Hearn Jay ^{[1
]}

Reddy, M. V. Ramana ^{[1
]}

Reddy, E. Premkumar ^{[1
]}

Parekh, Samir ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[2] Billings Clin Canc Ctr, Billings, MT USA

[3] Albert Einstein Coll Med, Albert Einstein Canc Ctr, Bronx, NY 10467 USA

[4] Beth Israel Deaconess Med Ctr, New York, NY 10003 USA

来源：

CANCER RESEARCH | 2014年 / 74卷 / 19期

关键词：

D O I：

10.1158/1538-7445.AM2014-1324

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1324

引用

页数：2

共 37 条

[1] Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma
Perumal, Deepak
Kuo, Pei-Yu
Leshchenko, Violetta V.
Jiang, Zewei
Divakar, Sai Krishna Athaluri
Cho, Hearn Jay
Chari, Ajai
Brody, Joshua
Reddy, M. V. Ramana
Zhang, Weijia
Reddy, E. Premkumar
Jagannath, Sundar
Parekh, Samir
CANCER RESEARCH, 2016, 76 (05) : 1225 - 1236
[2] Dual CDK4/ARK5 inhibition by ON 123300 for targeting metastatic colorectal cancer
Reddy, M.
Cosenza, Stephen
Divakar, Saikrishna
Akula, Balireddy
Mallireddigari, Muralidhar
Reddy, Premkumar
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
[3] Dual CDK4/ARK5 inhibition by ON 123300 for targeting metastatic colorectal cancer
Reddy, M.
Cosenza, Stephen
Divakar, Saikrishna
Akula, Balireddy
Mallireddigari, Muralidhar
Reddy, Premkumar
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
[4] Dual targeting of ARK5 and CDK4 pathways with ON 123300 as a therapeutic strategy for colorectal carcinoma
Divakar, Saikrishna A.
Reddy, M. V. Ramana
Cosenza, Stephen C.
Baker, Stacey J.
Purohit, Vinee
Gunda, Venugopal
Singh, Pankaj K.
Reddy, E. Premkumar
CANCER RESEARCH, 2016, 76
[5] Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats
Jennypher Mudunuru
Chen Ren
David R. Taft
Manoj Maniar
European Journal of Drug Metabolism and Pharmacokinetics, 2019, 44 : 531 - 538
[6] Effect of gender on the rodent pharmacokinetics of ON 123300, a dual inhibitor of ARK5 and CDK4/6, for the treatment of cancer
Ren, Chen
Mudunuru, Jennypher
Taft, David
Maniar, Manoj
CANCER RESEARCH, 2018, 78 (13)
[7] Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats
Mudunuru, Jennypher
Ren, Chen
Taft, David R.
Maniar, Manoj
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2019, 44 (04) : 531 - 538
[8] Novel cyano pyridopyrimidines as potent and selective inhibitors of CDK4 and Ark5 kinases
Akula, Balaiah
Athuluri, Saikrishna
Cosenza, Stephen C.
Kumar, Vinay
Reddy, E. Premkumar
Reddy, M. V. Ramana
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
[9] ON 123300, an orally administered novel CDK4/6+ARK5 inhibitor, exhibits potent antitumor activity in vivo: comparative studies with Palbociclib
Patel, Shraddha
Pancholi, Priya
Visal, Tanvi
Samant, Amruta
Kansara, Dhvanir
Rajadhyaksha, V. J.
Hoffman, Benjamin S.
Maniar, Manoj
Sehdev, Vikas
CANCER RESEARCH, 2017, 77
[10] Targeting of PI3K-a and CDK4/6 kinases in mantle cell lymphomas with dual kinase inhibitor ON 123300-lactate
Akula, Balireddy
Divakar, Saikrishna A.
Bharathi, Vijaya E.
Mallireddigari, Muralidhar R.
Subbaiah, D. R. C. Venkata
Pallela, Venkat R.
Billa, Vinay K.
Cosenza, Stephen C.
Reddy, E. Premkumar
Reddy, M. V. Ramana
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248

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