Studies on biologically active heterocycles. Part IX. Synthesis of 3-[5-{(2-chlorophenyl)-1,3,4-oxa/thiadiazolo}-2-yl]-1-aryl/substituted aryl thiobarbituric acids as probable antiparkinsonian agents

A series of new 3-[5-{(2-chlorophenyl)-1,3,4-oxadiazolo}-2-yl]-1-aryl/substituted aryl thiobarbituric acids (6a-h), 3-[5-{(2-chlorophenyl)-1,3,4-thiadiazolo}-2-]-1-aryl/substituted aryl thiobarbituric acids (7a-h), have been synthesized by reacting N-aryl/substituted aryl N-5-{(2-chlorophenyl)-1,3,4-oxa/thiadiazol-2-yl} thioureas (4,5) with malonic acid in presence of acetyl chloride. The structures of the newly synthesized compounds were elucidated on the basis of their elemental analysis, physical and spectroscopic data.