Analgesic-like Activity of Essential Oils Constituents

被引：132
|
作者：
de Sousa, Damiao Pergentino [1 ]
机构：
[1] Univ Fed Sergipe, Dept Physiol, BR-49100000 Sao Cristovao, SE, Brazil
来源：
MOLECULES | 2011年 / 16卷 / 03期
关键词：
analgesic; antinociceptive; essential oils; terpenes; natural products; BIOASSAY-GUIDED EVALUATION; LEAF ESSENTIAL OIL; PAW FORMALIN TEST; ANTINOCICEPTIVE ACTIVITY; ACETIC ACID; (-)-LINALOOL; EUGENOL; MODELS; INVOLVEMENT; NOCICEPTION;
D O I：
10.3390/molecules16032233
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Research on neuroactive drugs is a pharmaceutical sector of high interest and growth. The discovery of efficient drugs that can relieve pain is a subject of research in the pharmaceutical industry and academic field because pain is a symptom of many diseases. This review will summarize results on the discovery of essential oil constituents with analgesic-like activity from the chemical and pharmacological perspectives. Overall, 43 bioactive compounds were selected in nociception models. Among them, 62.8% were monoterpenes, 18.6% sesquiterpenes and other constituents represented 18.6%. The data show the potential of this group of natural product chemicals as analgesic drugs that may be useful for therapeutic purposes.
引用
收藏
页码：2233 / 2252
页数：20
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