Meticillin-resistant Staphylococcus aureus (MRSA) update: New insights into bacterial adaptation and therapeutic targets

被引：13
|
作者：
Purrello, S. M. [1 ]
Daum, R. S. [2 ]
Edwards, G. F. S. [3 ]
Lina, G. [4 ]
Lindsay, J. [5 ]
Peters, G. [6 ]
Stefani, S. [1 ]
机构：
[1] Univ Catania, Dept Biomed Sci, Microbiol Sect, Catania, Italy
[2] Univ Chicago, Dept Pediat, Infect Dis Sect, Chicago, IL 60637 USA
[3] Stobhill Hosp, Dept Microbiol, Scottish MRSA Reference Lab, Glasgow, Lanark, Scotland
[4] Fac Med Laennec, F-69372 Lyon 08, France
[5] Univ London, Div Clin Sci, London, England
[6] Univ Hosp Munster, Inst Med Microbiol, Munster, Germany
来源：
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | 2014年 / 2卷 / 02期
关键词：
MRSA; Horizontal gene transfer; agr locus; Panton-Valentine leukocidin; PVL; vraRS; PANTON-VALENTINE LEUKOCIDIN; HORIZONTAL GENE-TRANSFER; 2-COMPONENT REGULATORY SYSTEM; SMALL-COLONY VARIANTS; VIRULENCE DETERMINANTS; REDUCED SUSCEPTIBILITY; NASAL CARRIAGE; AGR DYSFUNCTION; RABBIT MODEL; STRAINS;
D O I：
10.1016/j.jgar.2014.02.003
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Successful meticillin-resistant Staphylococcus aureus (MRSA) clones have evolved to adapt to healthcare, community and livestock environments. This review will bring together recent studies into clone adaptation and the importance of genes acquired during horizontal gene transfer to survival in specific environments. It will also discuss the role of global regulators controlling virulence gene expression and resistance to antibiotics, such as the agr and vraRS systems. Understanding these processes in successful clones could reveal novel targets for therapeutic agents, which are urgently required to reduce the infection burden and improve treatment options. (C) 2014 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：61 / 69
页数：9
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