The Role of Biomarkers in Acute Kidney Injury

被引：80

作者：

Srisawat, Nattachai ^{[1
,2
,3
,4
,5
,6
]}

Kellum, John A. ^{[2
]}

机构：

[1] Chulalongkorn Univ, Fac Med, Div Nephrol, 3rd Floor,Anantamahidol Bldg,Henri Dunant Rd, Bangkok 10330, Thailand

[2] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Ctr Crit Care Nephrol,CRISMA Ctr, 3347 Forbes Ave,Suite 220, Pittsburgh, PA 15213 USA

[3] King Chulalongkorn Mem Hosp, Excellence Ctr Crit Care Nephrol, 1873 Rama IV Rd, Khet Pathum Wan 10330, Krung Thep Maha, Thailand

[4] Chulalongkorn Univ, Crit Care Nephrol Res Unit, 3rd Floor,Anantamahidol Bldg,Henri Dunant Rd, Bangkok 10330, Thailand

[5] Royal Soc Thailand, Acad Sci, 197 Rama 5 Rd, Bangkok 10300, Thailand

[6] Chulalongkorn Univ, Trop Med Cluster, 3rd Floor,Anantamahidol Bldg,Henri Dunant Rd, Bangkok 10330, Thailand

来源：

CRITICAL CARE CLINICS | 2020年 / 36卷 / 01期

关键词：

NGAL; TIMP-2; IGFBP7; KIM-1; IL-18; GELATINASE-ASSOCIATED LIPOCALIN; ACID-BINDING PROTEIN; CELL-CYCLE ARREST; RENAL REPLACEMENT THERAPY; CRITICALLY-ILL PATIENTS; URINARY BIOMARKERS; CARDIAC-SURGERY; LIVER-TYPE; RISK STRATIFICATION; MOLECULE-1; KIM-1;

D O I：

10.1016/j.ccc.2019.08.010

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Several biomarkers have been developed to detect acute kidney injury (AKI) and predict outcomes. Most AKI biomarkers have been shown to be expressed before serum creatinine and to be more sensitive and specific than urine output. Only a few studies have examined how implementation can change clinical outcomes. A second generation of AKI biomarkers have been developed. These markers, including tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulinlike growth factor-binding protein 7 (IGFBP7), have obtained regulatory approval in many countries based on large, rigorous clinical studies and small, single-centered trials and have begun to establish clinical utility.

引用

页码：125 / +

页数：17

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