A generic 3D kinetic model of gene expression

被引：1

作者：

Zhdanov, Vladimir P. ^{[1
,2
]}

机构：

[1] Chalmers Univ Technol, Dept Appl Phys, S-41296 Gothenburg, Sweden

[2] Russian Acad Sci, Boreskov Inst Catalysis, Novosibirsk 630090, Russia

来源：

CENTRAL EUROPEAN JOURNAL OF PHYSICS | 2012年 / 10卷 / 02期

关键词：

subcellular processes; gene transcription; mRNA synthesis; mRNA translation; mRNA and protein diffusion and degradation; SUBCELLULAR-LOCALIZATION; MESSENGER-RNA; DIFFUSION;

D O I：

10.2478/s11534-012-0011-5

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.

引用

页码：533 / 537

页数：5

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