The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation

被引：165
|
作者：
Callebaut, I
Courvalin, JC
Mornon, JP
机构：
[1] Univ Paris 06, CNRS, UMR 7590, LMCP, F-75252 Paris 05, France
[2] Univ Paris 07, CNRS, UMR 7590, LMCP, F-75252 Paris 05, France
[3] Univ Paris 07, CNRS, Inst Jacques Monod, F-75251 Paris 05, France
来源：
FEBS LETTERS | 1999年 / 446卷 / 01期
关键词：
DNA methyltransferase; Orc1; Sir3; ASH1; silencing;
D O I：
10.1016/S0014-5793(99)00132-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using sensitive methods of sequence analysis including hydrophobic cluster analysis, we report here a hitherto undescribed family of modules, the BAH (bromo-adjacent homology) family, which includes proteins such as eukaryotic DNA (cytosine-5) methyltransferases, the origin recognition complex 1 (Orc1) proteins, as web as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialized in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH module might therefore play an important role by linking DNA methylation, replication and transcriptional regulation. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码：189 / 193
页数：5
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