Two forms of long-term potentiation induced by different compounds

被引：5
|
作者：
Xu, L.
Wang, X.-Y.
Liu, S.-L.
Zhang, J.-T. [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2007年 / 9卷 / 03期
关键词：
clausenamide; Rg1; long-term potentiation; voltage-dependent calcium channels (VDCCs); N-methyl-d-aspartate glutamate receptor (NMDAR);
D O I：
10.1080/10286020500532066
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The purpose of this study was to investigate different forms of long-term potentiation (LTP) induced by different compounds. As shown in results, the influx of calcium via voltage-dependent calcium channels (VDCCs) was responsible for (2)-clausenamide-induced LTP in hippocampus, while Rg1 induced LTP is mediated by the entry of calcium via N-methyl-D-aspartate glutamate (NMDA) receptor. The findings in the present study provide pharmacological basis for the nootropic mechanisms of these two compounds.
引用
收藏
页码：217 / 222
页数：6
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