Cancer genetic predisposition: Current events and perspectives in 2010

被引：2
|
作者：
Stoppa-Lyonnet, D. [1 ,2 ]
Stern, M. H. [1 ]
Soufir, N. [3 ,4 ,5 ]
Lenoir, G. [6 ,7 ]
机构：
[1] Inst Curie, Serv Genet, Unite Inserm U830, F-75248 Paris 5, France
[2] Univ Paris 05, F-75270 Paris, France
[3] Hop Bichat Claude Bernard, AP HP, Lab Biochim Hormonale & Genet, F-75018 Paris, France
[4] Univ Paris 07, UFR Med, F-75018 Paris, France
[5] Hop St Louis, Ctr Rech Peau, F-75010 Paris, France
[6] Inst Gustave Roussy, Serv Genet, F-94805 Villejuif, France
[7] Univ Paris 11, F-91405 Orsay, France
来源：
PATHOLOGIE BIOLOGIE | 2010年 / 58卷 / 05期
关键词：
Hereditary cancer gene; Cancer susceptibility gene; Oncogene; Tumor suppressor gene; French National Cancer Institute; BREAST-CANCER; COLORECTAL-CANCER; MUTATION CARRIERS; FAMILIAL BREAST; OVARIAN-CANCER; BRCA2; RETINOBLASTOMA; IDENTIFICATION; ASSOCIATION; POPULATION;
D O I：
10.1016/j.patbio.2010.02.004
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Studies performed during these last 30 years have had a major impact on the understanding of carcinogenesis. They have opened a new field: cancer genetic predisposition. At the present time, most of the cancer predispositions linked to the alteration of one gene, associated with a high risk of cancer and with a specific phenotype have been identified. About 70 genes have been identified and have led to genetic testing. The indication of genetic testing, the management of at risk patients require the establishment of guidelines. The next challenge is the identification of cancer susceptibility genes associated with low risk or modifying the effect of treatment. (C) 2010 Elsevier Masson SAS. All rights reserved.
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页码：324 / 330
页数：7
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