Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital

被引:4
|
作者
de Hond, Titus A. P. [1 ]
Oosterheert, Jan Jelrik [2 ]
Van Hemert-Glaubitz, Susan J. M. [1 ]
Musson, Ruben E. A. [3 ]
Kaasjager, Karin A. H. [1 ]
机构
[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Internal Med & Acute Med, NL-3584 CX Utrecht, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Internal Med & Infect Dis, NL-3584 CX Utrecht, Netherlands
[3] Univ Utrecht, Univ Med Ctr Utrecht, Cent Diagnost Lab, NL-3584 CX Utrecht, Netherlands
来源
PATHOGENS | 2022年 / 11卷 / 05期
关键词
pancreatic stone protein; reg1a; sepsis; biomarker; emergency department; REG1A EXPRESSION; DEFINITIONS; INFECTION;
D O I
10.3390/pathogens11050559
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Early recognition of sepsis is essential for improving outcomes and preventing complications such as organ failure, depression, and neurocognitive impairment. The emergency department (ED) plays a key role in the early identification of sepsis, but clinicians lack diagnostic tools. Potentially, biomarkers could be helpful in assisting clinicians in the ED, but no marker has yet been successfully implemented in daily practice with good clinical performance. Pancreatic stone protein (PSP) is a promising biomarker in the context of sepsis, but little is known about the diagnostic performance of PSP in the ED. We prospectively investigated the diagnostic value of PSP in such a population for patients suspected of infection. PSP was compared with currently used biomarkers, including white blood cell count (WBC) and C-reactive protein (CRP). Of the 156 patients included in this study, 74 (47.4%) were diagnosed with uncomplicated infection and 26 (16.7%) patients with sepsis, while 56 (35.9%) eventually had no infection. PSP was significantly higher for sepsis patients compared to patients with no sepsis. In multivariate regression, PSP was a significant predictor for sepsis, with an area under the curve (AUC) of 0.69. Positive and negative predictive values for this model were 100% and 84.4%, respectively. Altogether, these findings show that PSP, measured at the ED of a tertiary hospital, is associated with sepsis but lacks the diagnostic performance to be used as single marker.
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页数:13
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