NLRP1, a regulator of innate immunity associated with vitiligo

被引：21

作者：

D'Osualdo, Andrea ^{[1
]}

Reed, John C. ^{[1
]}

机构：

[1] Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2012年 / 25卷 / 01期

关键词：

NLRP1; Vitiligo; inflammation; apoptosis; autocleavage; polymorphism; INFLAMMATORY CASPASES; CELL-DEATH; APOPTOSIS; ACTIVATION; RECEPTORS; FAMILY; PYRIN; NALP1;

D O I：

10.1111/j.1755-148X.2011.00942.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Some familial forms of the dermatological condition vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1. Here, we review what is currently known about the mechanisms that regulate activation of the NLRP1 protein and the downstream effects of NLRP1 on pathways impacting inflammation and apoptosis. How polymorphic variants of the NLRP1 gene contribute to the pathogenesis of vitiligo remains mysterious, requiring further investigation.

引用

页码：5 / 8

页数：4

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