HAEMATOLOGICAL ADVERSE EFFECTS OF INTERFERON AND RIBAVIRIN TREATMENT IN PATIENTS WITH CHRONIC C VIRUS HEPATITIS

被引：0
|
作者：
Taisescu, Citto Iulian [1 ]
Iliescu, Gabriela [2 ]
Taisescu, Oana [3 ]
Predescu, Anca [4 ]
Andrei, Ana Marina [5 ]
Catalin, Bogdan [1 ]
Silosi, Cristian [6 ]
Biciusca, Viorel [5 ]
机构：
[1] Univ Med & Pharm, Dept Physiol, Craiova 200349, Romania
[2] Cty Clin Emergency Hosp Craiova, Clin Lab, Craiova 200642, Romania
[3] Univ Med & Pharm, Dept Anat, Craiova 200349, Romania
[4] Clin Hosp Neuropsychiat Craiova, Clin Lab, Craiova 200473, Romania
[5] Univ Med & Pharm, Dept Semiol, Craiova 200349, Romania
[6] Univ Med & Pharm, Dept Surg, Craiova 200349, Romania
来源：
FARMACIA | 2015年 / 63卷 / 03期
关键词：
haematological abnormalities; interferon; ribavirin; C virus infection; THERAPY;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Haematological abnormalities were frequently found in chronic C hepatitis virus infection, but especially as complications of interferon-based antiviral therapy. The study of hematologic adverse reactions was initiated on a group of 30 patients with chronic hepatitis C, hospitalized in the IInd Clinic Medical Emergency Hospital Craiova, monitored and treated with peginterferon alfa-2b (PEG-IFN), 1.5 mu g/kgbw./week plus ribavirin (RBV) 1000-1200 mg/day for 12 months, within four years. The haemoglobin level decreased significantly when combining IFN with RBV. RBV induces anaemia, and in addition IFN inhibits the activity of hematopoietic bone marrow. Erythrocyte morphology provided information on viral activity, modifying with liver lesion progression and bone marrow infection, and the low number of reticulocytes confirmed both the toxic mechanism of IFN and a low regenerating bone marrow capacity.
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收藏
页码：465 / 469
页数：5
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