Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description

被引：14
|
作者：
Chen, Kerrie-Anne [1 ]
Brilot, Fabienne [2 ]
Dale, Russell C. [2 ]
Lafferty, Antony R. [3 ]
Andrews, Peter Ian [1 ,4 ]
机构：
[1] Sydney Childrens Hosp, Dept Paediat Neurol, Randwick, NSW, Australia
[2] Univ Sydney, Sydney Med Sch, Childrens Hosp Westmead,Brain & Mind Ctr, Brain Autoimmun Grp,Inst Neurosci & Muscle Res,Ki, Sydney, NSW, Australia
[3] Canberra Hosp, ANU Med Sch, Dept Paediat, Canberra, ACT, Australia
[4] UNSW, Sch Womens & Childrens Hlth, Sydney, NSW, Australia
来源：
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2017年 / 21卷 / 06期
关键词：
Hashimoto encephalitis; Myelin oligodendrocyte glycoprotein; Antibody; CLINICAL SPECTRUM; DIAGNOSIS; DISEASE;
D O I：
10.1016/j.ejpn.2017.06.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose: To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE). Results: A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs. Serum was positive for anti-myelin oligodendrocyte glycoprotein (MOG) Ab, implicating this antibody-mediated process in this patient's illness. Conclusion: We hypothesize that anti-MOG Ab associated demyelination may underlie a subset of patients with HE. (C) 2017 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：898 / 901
页数：4
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