C/EBPα deregulation as a paradigm for leukemogenesis

被引：51
|
作者：
Pulikkan, J. A. [1 ]
Tenen, D. G. [2 ,3 ]
Behre, G. [4 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, 364 Plantat St,LRB 670G, Worcester, MA 01655 USA
[2] Natl Univ Singapore, Canc Sci Inst, Singapore 117599, Singapore
[3] Harvard Med Sch, Harvard Stem Cell Inst, Boston, MA USA
[4] Leipzig Univ Hosp, Div Hematol & Oncol, Johannisallee 32A, D-04103 Leipzig, Germany
来源：
LEUKEMIA | 2017年 / 31卷 / 11期
关键词：
ACUTE MYELOID-LEUKEMIA; BINDING-PROTEIN-ALPHA; ACUTE MYELOGENOUS LEUKEMIA; GERMLINE CEBPA MUTATIONS; HEMATOPOIETIC STEM-CELLS; GRANULOCYTIC DIFFERENTIATION; TRANSCRIPTION FACTORS; ADULT HEMATOPOIESIS; INITIATING CELLS; CSF3R MUTATIONS;
D O I：
10.1038/leu.2017.229
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Myeloid master regulator CCAAT enhancer-binding protein alpha (C/EBP alpha) is deregulated by multiple mechanisms in leukemia. Inhibition of C/EBP alpha function plays pivotal roles in leukemogenesis. While much is known about how C/EBP alpha orchestrates granulopoiesis, our understanding of molecular transformation events, the role(s) of cooperating mutations and clonal evolution during C/EBP alpha deregulation in leukemia remains elusive. In this review, we will summarize the latest research addressing these topics with special emphasis on CEBP. mutations. We conclude by describing emerging therapeutic strategies to restore C/EBP alpha function.
引用
收藏
页码：2279 / 2285
页数：7
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