Targeting the liver circadian clock by REV-ERB-alpha activation improves liver fibrosis by circadian gating of TGF-beta signaling

被引：0

作者：

Dachraoui, Mayssa ^{[1
]}

Juhling, Frank ^{[1
]}

Roehlen, Natascha ^{[1
]}

Crouchet, Emilie ^{[1
]}

Martin, Romain ^{[1
]}

Brignon, Nicolas ^{[1
]}

Mailly, Laurent ^{[1
]}

Saviano, Antonio ^{[1
]}

Durand, Sarah ^{[1
]}

Schuster, Catherine ^{[1
]}

Felli, Emanuele ^{[2
]}

Pessaux, Patrick ^{[2
]}

Lupberger, Joachim ^{[1
]}

Mukherji, Atish ^{[1
]}

Baumert, Thomas ^{[3
,4
]}

机构：

[1] Univ Strasbourg, INSERM, Inst Rech Malad Virales & Hepat Inserm, UMR S1110, Strasbourg, France

[2] Univ Strasbourg, Inst Rech Malad Virales & Hepat Inserm, INSERM,UMR S 1110, Inst Hosp Univ,Pole Hepatodigestif,Nouvel Hop Civ, Strasbourg, France

[3] Univ Strasbourg, INSERM, Inst Rech Malad Virales & Hepat Inserm,UMR S1110, Inst Hosp Univ,Pole Hepatodigestif,Nouvel Hop Civ, Strasbourg, France

[4] Inst Univ France, Strasbourg, France

来源：

JOURNAL OF HEPATOLOGY | 2022年 / 77卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

OS038

引用

页码：S36 / S36

页数：1

共 29 条

[1] TARGETING THE LIVER CLOCK IMPROVES FIBROSIS BY RESTORATION OF TGF-& BETA; SIGNALING
Crouchet, Emilie
Dachraoui, Mayssa
Juhling, Frank
Roehlen, Natascha
Oudot, Marine
Durand, Sarah
Ponsolles, Clara
Gadenne, Cloe
Meiss-Heydmann, Laura
Moehlin, Julien
Martin, Romain
Brignon, Nicolas
Del Zompo, Fabio
Teraoka, Yuji
Aikata, Hiroshi
Abe-Chayama, Hiromi
Chayama, Kazuaki
Saviano, Antonio
Heide, Danijela
Felli, Emanuele
Pessaux, Patrick
Heikenwalder, Mathias
Chambon, Pierre
Schuster, Catherine
Lupberger, Joachim
Mukherji, Atish
Baumert, Thomas
HEPATOLOGY, 2024, 80 : S324 - S325
[2] Targeting the liver clock improves fibrosis by restoring TGF-β signaling
Crouchet, Emilie
Dachraoui, Mayssa
Juehling, Frank
Roehlen, Natascha
Oudot, Marine A.
Durand, Sarah C.
Ponsolles, Clara
Gadenne, Cloe
Meiss-Heydmann, Laura
Moehlin, Julien
Martin, Romain
Brignon, Nicolas
Del Zompo, Fabio
Teraoka, Yuji
Aikata, Hiroshi
Abe-Chayama, Hiromi
Chayama, Kazuaki
Saviano, Antonio
Heide, Danijela
Onea, Mihaela
Geyer, Lucas
Wolf, Thibaut
Felli, Emanuele
Pessaux, Patrick
Heikenwaelder, Mathias
Chambon, Pierre
Schuster, Catherine
Lupberger, Joachim
Mukherji, Atish
Baumert, Thomas F.
JOURNAL OF HEPATOLOGY, 2025, 82 (01)
[3] Circadian CLOCK mediates activation of TGF-β signaling and renal fibrosis through cyclooxygenase 2
Wang, C. -Y.
Chen, W. -D.
Peng, M. -T.
Wu, Y. -J.
FEBS JOURNAL, 2014, 281 : 258 - 258
[4] Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells
Okuno, M
Moriwaki, H
Imai, S
Muto, Y
Kawada, N
Suzuki, Y
Kojima, S
HEPATOLOGY, 1997, 26 (04) : 913 - 921
[5] Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro
Tang, Li-xia
He, Rui-hua
Yang, Guang
Tan, Jia-ju
Zhou, Li
Meng, Xiao-ming
Huang, Xiao Ru
Lan, Hui Yao
PLOS ONE, 2012, 7 (02):
[6] THE COMPARISON OF TGF-BETA 1/SMADS SIGNALING TRANSDUCTION PROTEIN LEVELS IN DIFFERENT LIVER FIBROSIS MODELS OF RATS
Li, X.
Chen, T.
Xiao, H.
Huang, Z. H.
Shuai, P.
Han, L. M.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2016, 119 : 27 - 28
[7] SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway
Zhang, Jinhang
Li, Yanping
Liu, Qinhui
Li, Rui
Pu, Shiyun
Yang, Lina
Feng, Yanhuan
Ma, Liang
RSC ADVANCES, 2018, 8 (54): : 30919 - 30924
[8] TGF-BETA SIGNALING IN HEPATOCYTES PROMOTES STEATOHEPATITIS AND LIVER FIBROSIS THROUGH MODIATING HEPATOCYTE DEATH AND LIPID ACCUMULATION
Seki, E.
Yang, L.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2014, 38 : 176A - 176A
[9] PKC Alpha/Beta Inhibition Attenuates Hypoxia Induced Interstitial Renal Fibrosis and Inflammation via Reduced Activation of TGF-Beta Signaling
Lu, X.
Rong, S.
Shushakova, N.
Kirsch, T.
Haller, H.
Gueler, F.
TRANSPLANTATION, 2012, 94 (10) : 1148 - 1148
[10] PKC ALPHA/BETA INHIBITION ATTENUATES HYPOXIA INDUCED INTERSTITIAL RENAL FIBROSIS AND INFLAMMATION VIA REDUCED ACTIVATION OF TGF-BETA SIGNALING
Lu, X.
Rong, S.
Shushakova, N.
Menne, J.
Kirsch, T.
Haller, H.
Gueler, F.
TRANSPLANT INTERNATIONAL, 2012, 25 : 9 - 9

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