Empowering Regulatory T Cells in Autoimmunity

被引：41

作者：

Kasper, Isaac R. ^{[1
]}

Apostolidis, Sokratis A. ^{[1
]}

Sharabi, Amir ^{[1
,2
]}

Tsokos, George C. ^{[1
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02215 USA

[2] Tel Aviv Univ, Sackler Fac Med, Dept Clin Immunol, IL-69978 Tel Aviv, Israel

来源：

TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 09期

关键词：

LOW-DOSE INTERLEUKIN-2; TRANSCRIPTION FACTOR FOXP3; X-LINKED SYNDROME; LUPUS-PRONE MICE; IMMUNE DYSREGULATION; SUPPRESSIVE FUNCTION; INDUCED ARTHRITIS; DOUBLE-BLIND; CIS-ELEMENT; ALPHA-CHAIN;

D O I：

10.1016/j.molmed.2016.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, including various transcription factors, phosphatases, and kinases, impact the ability of Tregs to function as negative regulators of the immune response, and are presumably amenable to therapeutic manipulation. Here, we discuss recently identified molecular networks and the therapeutic potential for treating autoimmune diseases.

引用

页码：784 / 797

页数：14

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