Long-term consequences of intrauterine growth retardation

被引:27
|
作者
Reynolds, RM [1 ]
Phillips, DIW [1 ]
机构
[1] Univ Southampton, MRC Unit, Southampton Gen Hosp, Metab Programming Grp, Southampton SO16 6YD, Hants, England
关键词
birth weight; fetal growth; programming; cardiovascular disease; type-2 (non-insulin-dependent) diabetes; hypertension;
D O I
10.1159/000053084
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recent studies in Europe, North America and the developing world have shown that low birth weight or other indices of abnormal fetal growth in babies born at term are linked with a higher prevalence of raised blood pressure, non-insulin-dependent diabetes and cardiovascular disease in late adult life. These findings have led to the 'fetal origins' hypothesis which proposes that fetal adaptations to an adverse intrauterine environment programme persistent physiological and metabolic changes which predispose to these diseases. The mechanisms are unknown, but evidence from animal studies and preliminary evidence in humans suggest that impaired fetal nutrient supply permanently alters neuroendocrine development in the offspring resulting in longterm changes in the set point of adrenocortical and sympathoadrenal hormonal activity.
引用
收藏
页码:28 / 31
页数:4
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