Objective Near infrared spectroscopy (NIRS) complements online monitoring of cerebral oxygenation during aortic arch surgery Its addition targets at an increase of safety of a complex procedure employing bilateral antegrade cerebral perfusion (BACP) and circulatory arrest under tepid blood temperatures We report the outcome of NIRS guided aortic arch surgery using BACP with moderate hypothermic circulatory arrest (MHCA) Methods Between December 2006 and December 2008, NIRS was used in 13 patients (mean age 67 5 +/- 11 3 years) undergoing aortic arch repair using BACP combined with MHCA The diagnosis was atherosclerotic thoracic aneurysms in eight and acute aortic dissection in five patients Seven patients had a hemi arch replacement, six underwent frozen stent graft arch replacement and four patients had concomitant procedures such as coronary artery bypass grafting (CABG) or aortic valve surgery Our regimen of employing an algorithm for adaptation of perfusion modalities included the threshold of the drop in regional cerebral oxygen saturation <55% and/or a drop in the total oxygen index (TOI) of 15-20% assessed by the means of NIRS Results The mean MHCA was 35 +/- 16 min and lowest bladder temperature was 26 +/- 1 2 degrees C The mean TOI pre MHCA was 66 +/- 6 5% Twelve out of 13 patients underwent bilateral perfusion because of unilateral drops below the threshold level of TOI (mean 44 +/- 7 9%) In three patients, an organic psychosyndrome was observed No patient developed permanent neurological dysfunction Conclusion NIRS guided BACP during MHCA allows a safe approach to complex aortic arch surgery The drop of brain oxygenation values in the contralateral hemisphere during unilateral ACP strongly suggests the routine use of BACP, when circulatory arrest under tepid temperatures is used (C) 2010 European Association for Cardio Thoracic Surgery Published by Elsevier B V All rights reserved
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No Gen Hosp, Dept Cardiothorac Surg, Sheffield S5 7AU, S Yorkshire, EnglandNo Gen Hosp, Dept Cardiothorac Surg, Sheffield S5 7AU, S Yorkshire, England
Senanayake, Eshan
Komber, Mohamed
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No Gen Hosp, Dept Cardiothorac Surg, Sheffield S5 7AU, S Yorkshire, EnglandNo Gen Hosp, Dept Cardiothorac Surg, Sheffield S5 7AU, S Yorkshire, England
Komber, Mohamed
Nassef, Ahmed
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No Gen Hosp, Dept Vasc Surg, Sheffield S5 7AU, S Yorkshire, EnglandNo Gen Hosp, Dept Cardiothorac Surg, Sheffield S5 7AU, S Yorkshire, England
Nassef, Ahmed
Massey, Nicholas
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No Gen Hosp, Dept Cardiothorac Anaesthesia, Sheffield S5 7AU, S Yorkshire, EnglandNo Gen Hosp, Dept Cardiothorac Surg, Sheffield S5 7AU, S Yorkshire, England
Massey, Nicholas
Cooper, Graham
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No Gen Hosp, Dept Cardiothorac Surg, Sheffield S5 7AU, S Yorkshire, EnglandNo Gen Hosp, Dept Cardiothorac Surg, Sheffield S5 7AU, S Yorkshire, England