Rapid Nonovershooting Control for Simultaneous Infusion of Anesthetics and Analgesics

We propose a rapid nonovershooting tracking controller for the continuous infusion of anesthetics and analgesics to prevent overdosing and other harmful side effects on patients. The controller utilizes a state feedback control design methodology for multi-input multi-output systems to achieve a closed-loop eigenstructure that yields a nonovershooting transient response. The method is combined with a global optimization method to achieve a rapid nonovershooting response. The controller uses an extended Kalman filter to estimate system states from measurable outputs, and integral control is added to achieve robust tracking. The performance of the method is simulated on 20 patient models in two groups, and the results are compared against another recent study from the biomedical control literature. Copyright (C) 2021 The Authors.