Highly sensitive luminescent lanthanide metal-organic framework sensor for L-kynurenine

L-kynurenine (L-kyn) is a marker of prostate cancer. At present, the expensive instruments are usually applied to detect L-kyn clinically, which limits its wide application for cancer diagnosis. Herein, three lanthanide metal-organic frameworks ([Ln(CHO2)(3)](n), Ln = Eu, Gd, and Tb) were designed and obtained, and detailly characterized by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and luminescence spectroscopy. Further study reveals that [Tb(CHO2)(3)](n) is a highly selective, ultra-sensitive, of strong anti-interference, highly stable, and non-expensive sensor for prostate cancer marker L-kyn. The limit of detection (LOD) for L-kyn sensing is a highly sensitive value of 1.0 x 10(-9) mol/L. Furthermore, the sensing mechanism is discussed in detail. (C) 2021 Chinese Society of Rare Earths. Published by Elsevier B.V. All rights reserved.