Chronic phenobarbital-induced mitochondrial pleomorphism in the rat liver

被引：2
|
作者：
Almsherqi, Zakaria
Mclachlan, Craig Steven
Tay, Stacey K. H.
Deng, Yuru
机构：
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Fac Med, Dept Physiol, Singapore 117597, Singapore
[2] ASTAR, Ctr Mol Med, Genet Med Grp, Singapore 136668, Singapore
[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119074, Singapore
来源：
TOXICOLOGIC PATHOLOGY | 2007年 / 35卷 / 06期
基金：
英国医学研究理事会;
关键词：
mitochondria; phenobarbital; liver; rat; electron microscopy; ultrastructure;
D O I：
10.1080/01926230701584171
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Posttreatment effects of phenobarbital (30 mg/kg I.P. per day for 5 days) on liver mitochondrial TEM ultra-structure in adult rats were studied. Liver mitochondria population samples in treated rats exhibited pleomorphic morphological dumbbell shapes (7%), U-type (crescent) shapes (4%) and O-type (ring-like) shapes (4%). This pathology was not observed in vehicle-treated animals. Phenobarbital is a drug that induces within the rat liver increased protein synthesis in the mitochondria and mitochondrial morphological shape changes.
引用
收藏
页码：831 / 833
页数：3
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