Safety and Efficacy of Clomiphene Citrate and L-Carnitine in Idiopathic Male Infertility A Comparative Study

被引：0

作者：

Moradi, Mahmoudreza ^{[1
]}

Moradi, Asaad ^{[1
]}

Alemi, Mohsen ^{[1
]}

Ahmadnia, Hassan ^{[2
]}

Abdi, Hossein ^{[1
]}

Ahmadi, Alireza ^{[3
,4
]}

Bazargan-Hejazi, Shahrzad ^{[5
]}

机构：

[1] Kermanshah Univ Med Sci, Fertil Infertil Res Ctr, Imam Reza Hosp, Urol & Nephrol Res Ctr, Kermanshah, Iran

[2] Mashhad Univ Med Sci, Dept Urol, Mashhad, Iran

[3] Kermanshah Univ Med Sci, Imam Reza Hosp, Dept Anesthesiol, Kermanshah, Iran

[4] Karolinska Inst, Dept Publ Hlth Sci, Div Social Med, Stockholm, Sweden

[5] Univ Calif Los Angeles, David Geffen Sch Med, Charles R Drew Univ Med & Sci, Dept Psychol,Coll Med, Los Angeles, CA 90095 USA

来源：

UROLOGY JOURNAL | 2010年 / 7卷 / 03期

关键词：

semen parameters; male infertility; randomized controlled trial; SPERM PARAMETERS; DOUBLE-BLIND;

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: To compare the effects of L-carnitine with clomiphene citrate in idiopathic infertile men. Materials and Methods: Fifty-two men with idiopathic infertility were recruited in this randomized controlled trial. They were randomly assigned into 2 treatment groups, group 1 (n = 20) and group 2 (n = 32), who received L-carnitine 25 mg/day and clomiphene citrate 2 gr/day, respectively, for a period of 3 months. Results: Comparing the effect of L-carnitine and clomiphene on sperm parameters before and after the treatment, both medications had influence on sperm count and motility (P = .01). L-carnitine significantly increased the-semen volume (P = .001), while clomiphene citrate was significantly associated with the motility percentage and normal morphology (P = .008). Conclusion: It seems that the use of clomiphene citrate and L-carnitine, either individually or in combination, as the first step of idiopathic male infertility treatment is reasonable, safe, and effective.

引用

页码：188 / 193

页数：6

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