The clinicopathological significance of p53 and p21 expression in squamous cell carcinoma of hypopharyngeal cancer

被引：13
|
作者：
Chien, CY
Huang, CC
Cheng, JT
Chen, CM
Hwang, CF
Su, CY
机构：
[1] Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung 833, Taiwan
[2] Kaohsiung Chang Gung Mem Hosp, Dept Pathol, Kaohsiung 833, Taiwan
[3] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 804, Taiwan
来源：
CANCER LETTERS | 2003年 / 201卷 / 02期
关键词：
p21; p53; hypopharyngeal cancer;
D O I：
10.1016/S0304-3835(03)00484-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To evaluate the roles of p53 and p21 expression in the squamous cell carcinoma of hypopharyngeal cancer, we performed the immunohistochemical studies in 58 patients with hypopharyngeal cancer. We found significant correlation between a high expression of p53 and a histological grade of well differentiation, advanced tumor (T) and TNM stage. Furthermore, low expression of p21 correlated significantly with advanced TNM stage and positive nodal status. Cox's regression analysis revealed tumor stage and nodal status were the only prognostic factors for survival. Therefore, we concluded that p53 and p21 are useful markers in predicting some clinicopathological features in hypopharyngeal cancer. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：217 / 223
页数：7
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