Non-canonical activation of Notch signaling/target genes in vertebrates

被引：69
|
作者：
Sanalkumar, Rajendran [1 ]
Dhanesh, Sivadasan Bindu [1 ]
James, Jackson [1 ]
机构：
[1] Rajiv Gandhi Ctr Biotechnol, Div Neurobiol, Neuro Stem Cell Biol Lab, Thiruvananthapuram 695014, Kerala, India
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 17期
关键词：
Notch signaling; CBF1-independent Notch; Hes-1; Non-canonical Notch; Neural differentiation; Tumorigenesis; NEURAL STEM-CELLS; BHLH TRANSCRIPTION FACTORS; RETINAL PROGENITOR CELLS; RBP-J; NEOPLASTIC TRANSFORMATION; INDEPENDENT PATHWAYS; FATE DETERMINATION; HES-1; EXPRESSION; BINDING PROTEIN; NERVOUS-SYSTEM;
D O I：
10.1007/s00018-010-0391-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.
引用
收藏
页码：2957 / 2968
页数：12
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