Dynamics of neutrophil migration in lymph nodes during infection

被引:314
|
作者
Chtanova, Tatyana [1 ]
Schaeffer, Marie [1 ]
Han, Seong-Ji [1 ]
van Dooren, Giel G. [2 ,3 ]
Nollmann, Marcelo [1 ]
Herzmark, Paul [1 ]
Chan, Shiao Wei [1 ]
Satija, Harshita [1 ]
Camfield, Kristin [1 ]
Aaron, Holly [1 ]
Striepen, Boris [2 ,3 ]
Robey, Ellen A. [1 ]
机构
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
[2] Univ Georgia, Paul Coverdell Ctr, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA
[3] Univ Georgia, Paul Coverdell Ctr, Dept Cellular Biol, Athens, GA 30602 USA
基金
英国医学研究理事会;
关键词
D O I
10.1016/j.immuni.2008.07.012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although the signals that control neutrophil migration from the blood to sites of infection have been well characterized, little is known about their migration patterns within lymph nodes or the strategies that neutrophils use to find their local sites of action. To address these questions, we used two-photon scanning-laser microscopy to examine neutrophil migration in intact lymph nodes during infection with an intracellular parasite, Toxoplasma gondii. We found that neutrophils formed both small, transient and large, persistent swarms via a coordinated migration pattern. We provided evidence that cooperative action of neutrophils and parasite egress from host cells could trigger swarm formation. Neutrophil swarm formation coincided in space and time with the removal of macrophages that line the subcapsular sinus of the lymph node. Our data provide insights into the cellular mechanisms underlying neutrophil swarming and suggest new roles for neutrophils in shaping immune responses.
引用
收藏
页码:487 / 496
页数:10
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