Skeletal Muscle Mitochondrial Energetic Efficiency and Aging

被引：20
|
作者：
Crescenzo, Raffaella [1 ]
Bianco, Francesca [1 ]
Mazzoli, Arianna [1 ]
Giacco, Antonia [1 ]
Liverini, Giovanna [1 ]
Iossa, Susanna [1 ]
机构：
[1] Univ Naples Federico II, Dept Biol, I-80126 Naples, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 05期
关键词：
mitochondria; aging; skeletal muscle; proton leak; OXYGEN SPECIES PRODUCTION; OXIDATIVE-PHOSPHORYLATION; PROTON LEAK; UNCOUPLING PROTEINS; CALORIC RESTRICTION; INSULIN-RESISTANCE; OLD RATS; IN-VIVO; AGE; CAPACITY;
D O I：
10.3390/ijms160510674
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is associated with a progressive loss of maximal cell functionality, and mitochondria are considered a key factor in aging process, since they determine the ATP availability in the cells. Mitochondrial performance during aging in skeletal muscle is reported to be either decreased or unchanged. This heterogeneity of results could partly be due to the method used to assess mitochondrial performance. In addition, in skeletal muscle the mitochondrial population is heterogeneous, composed of subsarcolemmal and intermyofibrillar mitochondria. Therefore, the purpose of the present review is to summarize the results obtained on the functionality of the above mitochondrial populations during aging, taking into account that the mitochondrial performance depends on organelle number, organelle activity, and energetic efficiency of the mitochondrial machinery in synthesizing ATP from the oxidation of fuels.
引用
收藏
页码：10674 / 10685
页数：12
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